Your grammar is a bit...ambiguous, but perhaps you mean "did Europe's navigable rivers and good natural harbors make trade difficult? If this is the case, then the answer is no. Rivers and harbors HELPED European trade. Goods could be moved up rivers or into natural harbors for docking, making trade easier.
yes
The Danube, the Elbe, the Rhine, the Volga, and the Seine rivers are some examples.
Europe has easy trade by water.
yes
Panama Canal
noting
There is no natural physical boundary between Europe and southwest Asia. -Apex
Spain.
River Thames
Western Europe has many bays, harbors, and peninsulas.
Most of Russia's deposits are in siberia, and they are difficult to get.
The Ural mountain range separates Europe from Asia. This range is difficult to cross and has been a natural barrier for centuries.