No.
Yes, there is a high-speed train connecting Madrid and Lisbon.
It takes about 6 hours from Madrid to Lisbon and the distance is about 628 kms by car.
There are 388 miles from Lisbon to Madrid. It's a long 6 hour drive.
Madrid and Lisbon
The travel time from Madrid to Lisbon on the high-speed train is approximately 2.5 to 3 hours.
380 miles
8 hours
6:66
I don't think that is possible.
Tagus
northeast
Lisbon is the second richest city in Iberia after Madrid. And it is one of the most beautiful city in Europe!