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MEPIS, or any other Linux distribution, is not directly compatible with Windows. Most files, like documents, movies, and music, can be used and enjoyed on MEPIS. MEPIS cannot natively support Windows programs. Wine, an application layer, can be used to run about 70% of Windows programs. MEPIS is not compatible with Windows drivers, though it has a program known as "ndiswrapper" to make a wireless card work with a Windows driver if Linux doesn't have one.

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