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No, Mewtwo cannot be caught in Route 224 unless an Action Replay was used. The only legitimate way in getting Mewtwo in Pokemon Platinum is by migrating it from Pokemon FireRed or LeafGreen to the Pal Park.
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Related Questions
What is route 224 in platinum?
You can't access Route 224 until professor Oak upgrades your Pokemon. Then go east of Victory Road. Route 224 is the eastmost Route in Diamond Pearl and Platinum.
Where do you get the Pokemon shaman in Pokemon Platinum?
You can get him/her on route 224
What Pokemon do you run into on route 224 in platinum?
lapras
Where is Route 224 in Pokemon Platinum?
First, go to the Pokemon Leauge.Then, right above the Pokemon League is route 224
Were do you get shaymin in Pokemon Platinum?
route 224. {flower paridise}
Where to find a trainer with hippottas in Pokemon platinum?
route 224
Where to find an octelary in platinum?
You can find them if you fish in route 224.
Where can you catch a duskull in Pokemon platinum?
Route 224 Poke Radar
Were do you get mew in platinum?
route 224 affter getting the nasinal pokedex
Where can you catch shymin in Pokemon platinum?
the flower paradise on route 224
Where do you find a trainer with finneon on Pokemon platinum?
Route 222 or 224.
Can you catch Natu on Pokemon Platinum?
They swarm occasionally on route 224
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