The venom of the Orb Weaver is potent, but not dangerous to humans. Its venom is a neurotoxin similar to that of the black widow. However, its venom is not near as potent.
Orb weavers are reluctant to bite. Symptoms are usually negligible or mild local pain, numbness and swelling, with redness and possibly blisters forming. Occasionally nausea and dizziness can occur after a bite. Any pain should go away within 24 hours.