Anguish would most often be a mood. Tone is the way the words are written, so the writer might be anguished, but usually not.
Anguish is a mood, as it refers to the emotional state or atmosphere being conveyed in a piece of writing. Tones, on the other hand, reflect the author's attitude and approach towards the subject matter.
mood sad tone depressing
stupid happy sad
The setting of the story does this.
Suspenseful is a tone
the tone is the mood that the auther creats
Tone is the kind of language used to set the mood.
not in the mood
what can be inferred about the mood, tone, and point of view of the author.
Mood
the tone of gifted hands was calm
what is the mood and tone of the poem silver
The mood is to live out loud.