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12mg of Suboxone is equivilant to 600mg of morphine. - FALSE

As a partial agonist opioid buprenorphine does not have a linear dose response curve like full agonist opioids do, including morphine. As such there is no direct conversion ratio that can be applied to all doses. At very low doses (<0.5mgs) buprenorphine is 20-50X as potent as morphine, however at higher dose (like those used to treat opioid dependence) buprenorphine is not 20-50x as potent and near or above the ceiling dose, equal doses of morphine becomes effectively more potent. Because buprenorphine has a ceiling to its effects, at and above the ceiling dose buprenorphine's dose response curve remains flat limiting its effects, while morphine (or any other full agonist opioid) continues to increase effect until the patient succumbs to respiratory depression. 32mgs of buprenorphine is NOT equal to 1600mgs of morphine which would kill just about anyone.

National Alliance of Advocated for Buprenorphine Treatment

Ref. TIP-40 (page 6)

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Wiki User

βˆ™ 13y ago
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Mateos Mind

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βˆ™ 1y ago
Having seen someone die off exactly 32 MGs of buprenorphine I wonder at the validity of this. People die from partial agonists all the time according to the FDA. They claim you can die from Kratom, yet every case they presented included multiple drugs.
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Anonymous

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βˆ™ 4y ago

Yes it is but there's a ceiling effect in bup. However, there's a growing epidemic of contaminated doses of many opiates being mixed w other drugs that make people get sick and could even cause death.

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Q: Is buprenorphine stronger than methadone
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