no. i dont think it is as long as you have the self control to limit your intake. if you do too much in a short amount of time or have an existing heart condition, you could have a heart attack. other than that, the only long-term effects is the depletion of your bank account (it is expensive), or you might get a deviated septum (hole in your nose). Who cares? you dont get liver cancer like drinking, or lung cancer from smoking. I would rather do blow than any other drug out there. period.