No it isn't; the two words have entirely different meanings.
The best synonym for vacuous is 'intelligent'
Clever Intelligent
Intelligent
Analytical, intelligent, pertinent, etc.
no it is not... "ponder" and "wonder", however, are
Smart, intelligent, perceptive
Many people believe that creationism is a one word synonym for intelligent design. Though this is not true, I hope it may be the answer you are looking for.
smart
Perceptive, intelligent, clever, savvy, perspicacious, canny, sharp...
Genius Intellectual Smart Academic brilliant brainy intelligent
A synonym for the word "inane" is idiotic. An antonym for "inane" is intelligent. Please see the related link below.
Intelligent....Some synonyms for smart are:intelligent, astute, sharp, shrewd, clever;or fashionable, chic, voguish;or forward, fresh, impertinent, impudent;or sting.