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ibuprofen and methadone are in 2 diffrent classes of drugs while the percocet and methadone are both opiates methadone is an opiate blocker in itself so it will highly effect the the strength of the percocet........ ive been on methadone and had to find the same question out 4 myself....

i am not a doctor nor have i had any medical experience answer is strictly based on personal knowledge and experience.....

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