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Yes, it is not uncommon for anti-depressants to "poop out" after taking them long term. It is not that you are resistant; your body has adjusted to the medication by changing the number of receptors involved in how the medication works. Talk to your doctor - he/she may increase the dose or switch you to another drug.

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Q: Is it possible to become resistant to Prozac I have been taking it for the past couple of years and recently feel as though it's not working as well?
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