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Yes it is. That is called ovarian torsion and can become a medical emergency. Typically, cysts are what cause this. The weight of a large ovarian cyst could cause an ovary to twist. If it twists a lot, the blood supply to the ovary could become compromised, and the ovary may start to die through the process known as gangrene. Then blood poisoning could result.

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Q: Is it possible to twist an ovary?
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