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Yes, my doctor told me I could take benedryl which is the same as diphenhydramine with my Wellbutrin. Even tylonol PM which has benedryl in it, the only thing is Wellbutrin dries your sinuses and so does diphenhydramine, that makes for a major headache.

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12y ago
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11y ago

i don't know but i just did it

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Q: Is it safe to take Wellbutrin with diphenhydramine?
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