Is lupus anticoagulant hereditary

Answer 1

Researchers have found some genes that are more prevalent in lupus patients, suggesting they may be at least in part responsible for the heritability of the disease. Research however, continues.

What Are Researchers Trying to Learn About Lupus?

Current lupus research projects include:

• A Specialized Center of Research in Lupus at the University of Virginia School of Medicine
• A Lupus Registry and Repository that researchers across the country can utilize to help identify genes that determine susceptibility to the disease
• A Neonatal Lupus Registry that researchers across the country can utilize to research data and genetic information on neonatal lupus
• Funding for The Lupus Federal Working Group-to focus on lupus research progress
• Research studies to better understand:
  • Genetics-genes that are associated with susceptibility to lupus or play a role in the development of lupus
  • Biomarkers-something that can be found in cells or tissues that predicts lupus flares or lupus disease process
  • The lupus disease process-how it affects different organs, how it behaves in its earliest clinical manifestations
  • Treatments, such as the medication rituximab, which lowers the number of white blood cells that produce antibodies
  • Overcoming barriers that tend to keep some populations from complying with prescribed treatment.

Science has located genes that are more prevalent in lupus patients, indicating a possibility that they could be responsible at least in part for the disease.
Lupus

is hereditary.
Lupus

is hereditary.

Answer 2

The cause and cure for lupus are not known at this time. Researchers believe that lupus develops when a person with just the right combination of genes encounters triggers, either extreme or over an extended period of time. All of the genes have not been identified nor have all the triggers. Lupus is not directly inherited. In fact, there are cases of genetically identical twins where one develops lupus and the other does not. This supports the idea that it takes both genetic predisposition AND triggers. Daneil Wallace, MD provides a thorough discussion on this topic in The Lupus Book.

Answer 3

Lupus is thought to be a genetic disease, however, unlike other genetic factors and diseases, lupus doesnt seem to follow a pattern. This may be due to a lack of diagnosis only generations ago. However, It seems that those with lupus may not have a family history of it but rather a family history of various autoimmune disorders such as RA. suggesting autoimmunity may be genetic but the presentation of an autoimmunity may vary.

Answer 4

Researchers have found a genetic component in lupus. There are places on the human genome that have been implicated. That said, there are many cases of identical twins where one develops lupus and the other does not. This suggests that environmental triggers are also implicated. Furthermore, there are people who can't identify a single relative with lupus but yet they develop the disease. See the related link.

Answer 5

Lupus is commonly passed on genetically but it can also be caused by some drugs.