Thrombin
prothrombin time, hematocrit
The INR has basically replaced the prothrombin time, or PT.
The prothrombin test specifically evaluates the presence of factors VIIa, V, and X, prothrombin, and fibrinogen.
the Liver
liver
prothrombin time
It is formed in the liver
Thromboplastin -> Prothrombin -> Thrombin -> Fibrinogen -> Fibrin
Vitamin K corrects prothrombin in the setting of biliary obstruction but not of hepatocellular damage.
inadequate synthsis of prothrombin
inhibiting the formation of prothrombin activator and the action of thrombin on fibrinogen