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What enzymes in the glycolysis pathway in the liver catalyze irreversible reactions?
Glucokinase, phosphofructokinase-1, pyruvate kinase
How does pyruvate kinase deficiency affect the body?
PKD is caused by a deficiency in the enzyme, pyruvate kinase.
What is pyruvate kinase?
Pyruvate kinase deficiency (PKD) is part of a group of disorders called hereditary nonspherocytic hemolytic anemias.
The enzyme pyruvate kinase is responsible for catalyzing the conversion of phosphoenolpyruvate into?
pyruvate
Is magnesium a cofactor of glycolysis?
Yes, Mg2+ is a cofactor for the enzymes phosphofructo kinase-1, phosphoglycerate kinase, enolase, and pyruvate kinase in glycolysis.
Which enzyme(s) bypass the pyruvate kinase reaction of glycolysis in gluconeogenesis?
pyruvate carboxylase and phosphoenolpyruvate carboxykinase (PEPCK)
What enzyme is responsible for aerobic respiration?
There are very many enzymes involved. A few from glycolysis are: hexokinase and glucokinase, phosphohexose isomerase, phosphofructokinase, pyruvate kinase; from pyruvate decarboxylation are pyruvate dehydrogenase phosphatase and pyruvate dehydrogenase kinase; and a few from the Kreb's cycle are: aconitase, alpha-ketoglutamate dehydrogenase, succinate thiokinase, and fumarase.
How is PKD measured?
A diagnosis of PKD can be made by measuring the amount of pyruvate kinase in red blood cells.
Muscle cells when an individual is excerising heavily and when the muscle becomes oxygen deprived convert pyruvate to lactate What happens to the lactate in the skeletal muscle cells?
The lactate is taken to the liver and converted back to pyruvate.
Who is most likely to get pyruvate kinase deficiency?
Caucasians of northern and central European decent are more likely to have the 1529A mutations, individuals of southern European descent usually have the 1456T mutation,
What has the author Philip Dykshoorn written?
Philip Dykshoorn has written: 'Identification of an upstream activating sequence of the yeast pyruvate kinase gene (PYK)'
What is used in glycolysis?
this is shamefully vague question. In glycolysis, glucose and (hexokinase, phosphogluco-mutase, aldolase, triose-phosphate isomerase, glyceraldehyde-phosphate dehydrogenase, phosphoglycerate-kinase, phosphoglycerate mutase, enolase and pyruvate kinase) enzymes are used.
