In most schools YES! Especially the southern states. They try to maintain a large % that are instate residents. And only those with impressive academic scores and amazing EC's will be accepted. Now Harvard, Hopkins, Vanderbilt, and other places such as those will not matter so much. All they care about is having a 3.8+ with EC's such as going on missionary trips to 3rd world countries and saving children from starvation and/or curing cancer (Had to add some sarcasm ;)).