Not that I have ever heard of.
The killer in Scream is known as Ghostface. In the movie he is a serial killer, but he is a fictional character.
The movie "Henry Portrait of a Serial Killer" was released in the year of 1986. The plot of the movie, "Henry Portrait of a Serial Killer" is a scary mystery based on a true story.
fredy vs Jason
chucky
chucky is a serial killer from the movie child's play.
jill
In the movie The Red Dragon, Francis Dolarhyde is a fictional character and the main antagonist. He was called the tooth fairy. He was the serial killer in that movie.
Barre le fong does
He is actually a serial killer
In the Dario Argenta Movie "Giallo" Adrian Brody plays a dual role as both the FBI agent looking for the serial killer whose skin is yellow or giallo in Italian and the serial killer. It's a cool movie I thought in spite of the dramas associated it.
I know what you did last summer
Michael Myers and Jason Voorhees.