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Take I-35 SOUTH to I-80 WEST in Des Moines, Iowa.Continue on I-80 WEST to Omaha.
525 miles. This is the best route:Take I-74 WEST to I-80 WEST to DAVENPORT. Continue STRAIGHT on I-80 WEST.Take I-80 WEST to Omaha.
Follow I-35 NORTH from Wichita to I-29 NORTH via I-435 WEST (EXIT 222B off I-35) & NORTH to bypass KANSAS CITY.Take I-29 NORTH to I-80 WEST to OMAHA or I-480 WEST to DOWNTOWN OMAHA in Council Bluffs, IOWA (right across the river from Omaha), then take I-80 WEST to Omaha.
80 miles taking this route:Take I-80 WEST (towards LINCOLN), from Omaha, to N-103 to CRETE off EXIT 388.Take N-103 SOUTH to Crete.
1,435 miles taking this route:Take I-90 EAST from Spokane to I-29 SOUTH to SIOUX CITY at EXIT 396A, near Sioux Falls, SOUTH DAKOTA.Take I-29 SOUTH to OMAHA. To get to Omaha itself, take either I-680 WEST (EXIT 61B in IOWA) (to NORTHERN Omaha), I-480 WEST (to DOWNTOWN) (EXIT 53B in IOWA), or I-80 WEST (EXIT 51 in IOWA).
Take I-70 WEST to I-465 SOUTH at EXIT 90 in Indianapolis, Indiana.Take I-465 around Indianapolis to I-74 WEST to PEORIA, IL at EXIT 16B.Take I-74 WEST to I-80 WEST to DAVENPORT in Illinois near the Quad Cities. Continue straight on I-80 WEST. In Illinois you will bypass Peoria by taking I-474 WEST (EXIT 99 of I-74 to get onto I-474 WEST then exit at EXIT B at END I-474 to get back onto I-74 WEST).Take I-80 WEST briefly through Illinois, then through Iowa, Nebraska and Wyoming to I-84 WEST to OGDEN at EXIT 168 in Utah. On I-80, you will bypass Omaha, NE by taking I-680 WEST (EXIT 27 off I-80 in IOWA).Take I-84 WEST to Portland.
Take I-80 EAST to Omaha.
1,850 miles taking this route:Take I-29 SOUTH from Sioux Falls to I-80 WEST to OMAHA at EXIT 51 in Council Bluffs, IOWA.Take I-80 WEST to San Francisco.
I think you mean Fargo, North Dakota; there is no Fargo is South Dakota.As for the route:Take I-70 WEST to I-70/76 Pennsylvania Turnpike (toll road) WEST to PITTSBURGH in Breezewood, PA. Follow signs.Take the Pennsylvania Turnpike WEST on I-70/76 and I-76 to Ohio where it becomes the Ohio Turnpike (toll road). Take the Ohio Turnpike (toll road) WEST on I-76, I-80 and I-80/90 to Indiana where it becomes the Indiana TOLL ROAD.Take the Indiana TOLL ROAD WEST on I-80/90 to I-80 WEST at EXIT 21 in northeastern Indiana (Chicagoland).Continue on I-80 WEST through Indiana and Illinois to I-680 WEST to NORTH OMAHA and SIOUX CITY at EXIT 27 in Iowa.Take I-680 WEST to I-29 NORTH to SIOUX CITY at EXIT 13B.Take I-29 NORTH through Iowa and South Dakota to Fargo, NORTH DAKOTA.
The driving distance from Minneapolis, Minnesota to Reno, Nevada is 1,750 miles.Although taking this faster route is 1,825 miles:Take I-35 SOUTH, from Minneapolis, to I-80 WEST to COUNCIL BLUFFS and OMAHA, in IOWA.Continue on I-80 WEST to Reno.
1,743 miles taking this route:Take I-80 WEST from Omaha to HIGHWAY 99 SOUTH via I-580 - CAPITOL CITY FWY thru SACRAMENTO in CALIFORNIA.Take HIGHWAY 99 SOUTH towards FRESNO, to Fresno.
80