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Looking at your motherboard, the RX 480 will work with your rig no doubt.

Just a suggestion, depending on what games you play, you could get a Geforce GTX 1050 Ti, as it is more than $100 dollars less, and can still run games very nicely with decent frames.

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Q: Looking into buying a better graphics card than AMD Radeon HD 6450. Currently have MSI 760GM-P23 motherboard AMD FX4300 processor and 750W power supply. Will a Radeon RX480 work with this setup?
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