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Well, there is not really a short answer for it:

1) there are 2 class of MHC:

HLA/MHC-I: binds to CD8 T cells

HLA/MHC-II: binds to CD4 T cells

A physician has to check for a good match of the MHC subtypes in a transplation between graft and host. A good match reduces the risk of immune complications after the transplantation.

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