There are pages and pages of things that can cause a check engine light. You need to have it checked with a scantool. Then the code can be diagnosed and repaired.
The Lexus LFA has a 4.8L V10 Engine.
The 2013 Lexus IS-350 has a V6 engine.
The 2012 Lexus IS-350 has a V6 engine.
The 2010 Lexus IS-250 has a V6 engine.
The 2011 Lexus IS-350 has a V6 engine.
The 2010 Lexus IS-F has a V8 engine.
The 2009 Lexus IS-F has a V8 engine.
The 2013 Lexus IS-F has a V8 engine.
The 2011 Lexus IS-250 has a V6 engine.
The 2010 Lexus IS-350 has a V6 engine.
The 2007 Lexus IS-350 has a V6 engine.
The 2012 Lexus LFA has a V10 engine.