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it is secreted by stomach glands as an inactive proenzyme, pepsinogen, which is converted to pepsin by the cleavage of acid-labile linkages in the acidic (low pH) environment of the stomach.

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Why is pepsin secreted as an inactive precursor called pepsinogen?

Pepsinogen is secreted as an inactive precursor because pepsin is a proteolytic enzyme that can damage the cells that produce it. By secreting pepsinogen, the stomach protects itself from self-digestion until it is needed to break down proteins in the stomach.


Gastrin secretes what?

pepsinogen (a precursor of pepsin) which helps humans digest, when activated by HCL.


Is there chemical digestion that takes place in the stomach?

Yes, absolutely.The stomach secretes digestive juices that are mostly involved in digesting proteins. This is a chemical digestion process that mostly involves hydrochloric acid and pepsinogen, secreted by the parietal cells and chief cells.


Hydrochloric acid is secreted by what cell?

Hydrochloric acid is secreted by the parietal cells in the stomach. They are responsible for producing the acidic environment necessary for digestion and killing bacteria in the stomach.


Hydrochloric acid is secreted by which of the secretory cells of the stomach?

Hydrochloric acid is secreted by the parietal cells in the stomach lining. These cells are responsible for producing the acidic environment in the stomach that aids in digestion.


Protein digestion in the stomach results primarily from secretions released by what?

Protein digestion in the stomach results primarily from secretions released by the gastric glands. The enzyme that is secreted is called pepsinogen.


What is the source of pepsin?

Pepsin is an enzyme which is secreted by Zymogen cells of the stomach. First it is secreted in an inactive form called Pepsinogen. After that Hydrochloric acid (HCl) activates it into pepsin. FUNCTION:Its function is to hydrolyse the proteins to yield peptide.


What is the difference between pepsin and pepsinogen?

Pepsin is a powerful protein digesting enzyme which is far too dangerous in its active form so it is released in an inactive pepsinogen form by the cell and activated only in the digestive tract where it is required to be active.


What substance that is secreted by the parietal cells of the stomach?

Three substances secreted by the stomach are: 1) Hormones. The most important of these is gastrin, which is secreted by the stomach's G cells. Gastrin is an important hormone in digestion, in that it brings about the stimulation of parietal cells to produce gastric juice, which contains the acid HCl, water, and pepsinogen (a precursor to pepsin). Gastrin is released in response to distention of the stomach, stimulation of the vagus nerve or degranulation of mast cells to give histamine. Gastrin secretion is inhibited by the presence of acid (a form of self-regulative negative feedback) and also the hormones secretin and somatostatin. 2) Acid. The HCl secreted by parietal cells into the lumen of the stomach serves a number of functions. It creates an acidic environment that kills bacteria, denatures protein, hydrolyses the zymogen pepsinogen to its active form, pepsin and provides the optimum pH for pepsin action. 3) Mucus. Mucus is secreted by the gastric gland's mucus cells and, to a lesser extent, mucus neck cells. Mucus is a cloudy, viscous and alkaline substance that forms a thick gel-like coat that adheres to the surface epithelium and protects it from abrasion and the acid content of the stomach. 4) Another important secretion is preoteases, such as pesinogen and rennin.


What cells secrete hydrochloric acid?

Chief cells lining the stomach. (They actually secrete H+ and Cl- ions individually, but it becomes HCl in the solution).


Why can pepsin not be produced in its active form?

Pepsin degrades proteins so if it was active it would immediately begin digesting all the proteins in the cell. Therefore it is produced from a precursor known as a zymogen or proenzyme. Pepsin's proenzyme form is pepsinogen which is transformed to the activated pepsin protein.


Where is hydrochloric acid secreted in the digestive system?

Hydrochloric acid is secreted by the parietal cells in the stomach. These cells are located in the gastric glands lining the stomach wall. Hydrochloric acid plays a key role in the digestion of food by creating an acidic environment in the stomach.