According the AA Route Planner (GB Edition) the distance is 188.7 miles, this will take about 3 hours and 27 minutes to drive, assuming you take the direct route to the centre of each location and there are no stops, accidents, breakdowns or other hold ups en route.
165 miles taking this route:
London/Manchester is 196 road miles, 3.5 hours to drive
The nearest point in the country of Wales to the city of Manchester, England, is on the border between the two countries just west of Chester, England, a distance of about 35 miles.
The distance between Cardiff, UK and Abergavenny, UK is about 32.1 road miles.
The driving distance is approximately 190 road miles.
The distance between Manchester, England and Holyhead, Wales is about 120 road miles or 193 km.
16 miles taking M4.
180 miles or 290km by road.
261 miles or 420km by road.
27.3 road miles.
359km
The driving distance from Alicante to Manchester is 1,471 road miles.
The driving distance is approximately 27 road miles.
207 road miles / 333km
It is approximately 280 miles by road.