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Steroid hormones diffuse into cells being lipid-soluable and may enter any cell in the body. They bind a specific protein molecule - the receptor. This activates mRNA transcription.
Steroid hormones diffuse into cells being lipid-soluable and may enter any cell in the body. They bind a specific protein molecule - the receptor. This activates mRNA transcription.
tyrosine kinase receptor!!
is a molecule inside a cell
steroid hormones are hydrophobic and bind to transport proteins which bind to receptors within the nucleus. hydrophillic hormones bind to plasma membrane receptors and act through second messenger systems
because they cannot cross cell membranes
This is because they do not have the ability to pass through the membrane, unlike steroid hormones. Steroid hormones bind inside the cell cytoplasm before docking onto the receptors.
steroid hormones can pass easily through the plasma membrane, the hormones then bind to intracellular receptors which induce a metabolic pathway which later promotes transcription of a specific gene.
Hormones do not bind to receptors with high capacity. The major defining properties of a hormone-receptor interaction, and what determines the strength of response is binding affinity and efficacy.
steroid
steroid
Steroid hormones pass through the cell membrane and bind to a specific steroid hormone receptor protein. The combined steroid and receptor protein then bind to a specific sequence of bases in the DNA molecule. This sequence of bases is part of the promotor of a gene. Binding of the steroid - receptor complex either activates (switches on) or represses (switches off) the gene which is controlled by that promotor. If the gene is switched on then it will produce mRNA (transcription) which will lead to the sysnthesis of protein (translation). If the gene is switched off then mRNA will not be produced and no protein will be synthesised. In summary, steroid hormones can act to operate 'switches' for genes, switching protein synthesis on or off. See: http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/SteroidREs.html http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Promoter.html http://biology.about.com/od/cellularprocesses/a/aa073004a.htm http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/moaction/intracell.html