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The process by which cholesterol is transported into the cell by binding of LDL to its receptor and the internalization of the receptor-LDL complex is?
Wiki User
∙ 13y ago
facilitated transport
Wiki User
∙ 13y ago
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What is receptor internalisation?
Receptor internalization is the process by which cell surface expressed receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into the endocytic vesicles to the lysosome. The receptor will either be degraded or brought back to cell membrane were it is again able to interact with its ligands. Receptor internalization serves as a mechanism to downregulate receptor signaling upon agonistic ligand stimulation.
Does cholesterol function as a hormone receptor in the plasma membrane?
NO!
What is the importance of Receptor-mediated Endocytosis in the genetic disorder Familial Hyper-Cholesterolemia?
In mammalian cells, the LDL (low density lipoprotein) receptor transports cholesterol into the cell via receptor-mediated endocytosis. The cholesterol is then used by the cell for various metabolic functions and the receptor is recycled to the plasma membrane.In patients suffering from Familial Hypercholesterolemia, the genes encoding the LDL receptor are mutated, as a result of which cholesterol is unable to bind to the LDL receptor. This leads to accumulation of cholesterol in the circulation, hence causing disease. Patients suffering from this disease are treated using drugs called Statins, which inhibit an important enzyme involved in cholesterol biosynthesis.
What process does cholesterol enter the cell?
receptor-mediated endocytosis.
How does insulin enter animal cells?
Cholesterol enters animal cells when the animal consumes and processes something that contains cholesterol. The cholesterol then enters through the cells permeable surface.
What are the four types of protein in a cell membrane?
transport proteins receptor proteins enzyme proteins cholesterol
What types of ligands enter by receptor-mediated endocytosis?
Cholesterol metabolism is a very well studied example of RME.
Which lipoprotein contains the highest percentage of cholesterol?
HDL has the highest percentage of proteins. LDL has the highest percentage of cholesterol plus cholesteryl esters. LRP is the abbreviation for LDL receptor related protein.
What are the differences between receptor desensitization and down regulation?
Desensitization is where the receptors become phosphorylated and therefore inactive but remain on the plasma membrane. Down regulation is any scenario where there are less numbers of receptors on the plasma membrane. So this can include internalization.
Are hormones transported throughout the whole body?
Yes. Hormones are transported throughout the body, via the bloodstream. They do not, however, effect every cell. Only certain cells in the body have the proper receptor sites to accomodate hormones. Therefore, even though hormones are transported right through the body, they only create a reaction for certain things.
Is coffee bad for high cholesterol?
Yes, in a round about way. Coffee has no cholesterol. Cholesterol in the diet only comes from animal products, no plants have cholesterol. Cholesterol is produced by the liver in animals. Coffee however does have cafestol which activates an acid receptor called FXR that affects how the liver regulates the cholesterol it produces, in effect elevating cholesterol levels in the blood. Cafestol is present in the natural oils of the coffee bean, paper filters used in brewing coffee can trap those oils and in effect reduce the cafestol in the brewed coffee.
What are important tissue receptor tumor markers?
estrogen receptor, progesterone receptor, interleukin-2 receptor, and epidermal growth factor receptor.
