Meddlesome usually refers to a person who likes to meddle, or interfere, in the business of others. For instance, "She was a very meddlesome person who always gossiped about others. "
those meddlesome kids
he was very meddlesome
I was told by a meddlesome acquaintance that my two brothers had a fight.
My boss is a meddlesome nuisance.
"I would have gotten away with it if it weren't for you meddlesome kids!"
Pat is so meddlesome, bothering me when I'm doing my science project. -- "Argh! What meddlesome teenagers those people from Scooby Doo were!" Honestly, it is just an adjective and can go before any noun. "What a meddlesome lamp post! He's making shenanigans of my darkness!"
A meddlesome cat is a cat without a tail.
I believe you mean meddlesome, as middlesome isn't a word. If someone is meddlesome it means someone who is constantly interfering (or meddling).
Meddlesome Mike - 1914 is rated/received certificates of: UK:U
interfering, invasive, meddlesome, meddling, nosy*, presumptuous, protruding, prying
Troublesome
"Yenta" - A person, especially a woman, who is meddlesome or gossipy.