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Vertebrates have backbones, or spinal columns, invertebrates don't. The spinal column is made up of individual bone segments called vertebra which is where the name comes from. The vertebra protect the spinal cord and major nerve roots branch off from the spinal column through spaces between the vertebra.

Ivertebrates tend to have less organized nervous systems with larger nerve bundles called ganglia rather than brains like vertebrates. Invertebrates also do not have internal skeletal systems. They may have what is known as a exoskeleton ("exo" meaning outside or external) like the shell on a lobster.

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