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The tetranucleotide hypothesis said that DNA wasn't diverse enough to be the hereditary/genetic material.

In case anyone gets confused (just indulge me so that I can feel smart), let me explain what the tetranucleotide hypothesis was.

It was hypothesized by Phoebus Levene in 1910, a bit after he identified the components of DNA. He proposed that the four nucleotides (adenine, thymine, cytosine, and guanine) occurred in equal quantities - as in A=T=C=G. This idea was extended to the point where it was widely believed that these four nucleotides continued in a repetitive pattern. Because of this, DNA didn't seem like a likely candidate for genetic material. Instead, proteins (the histones in chromosomes) were believed to be the real genetic material.

This belief was held steadfastly because Levene was widely respected. Sadly, many scientists second guessed themselves or were not taken seriously because of this hypothesis. Avery&McCarty&MacLeod met such criticism.

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13y ago
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13y ago

TOTALLY incorrect. If it was, DNA would not be a viable genetic material. And every science text book ever made will have to be rewritten.

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Q: Was the tetranucleotide hypothesis in DNA correct or incorrect?
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