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The Cardinal runs from Chicago to Cincinnati leaving on Tuesday, Thursday and Saturday and returning from Cincinnati on Monday, Thursday and Saturday. From Chicago to Cincinnati the Cardinal leaves at 5:45 pm and arrives in Cincinnati at 3:17 am the next day. Returning from Cincinnati the train leaves at 1:10 am and arrives in Chicago at 10:35 am.

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15y ago
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13y ago

Louisville does not Amtrak service at this time. The closest station is in Cincinnati. The Cardinal goes from Cincinnati to New York's Penn Station three days week in about 18 1/2 hours.

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12y ago

Amtrak

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Q: What train from Cincinnati to Louisville?
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