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Early European settlers into the America's encountered a series of common difficulties. Issues with drinking water and disease killed many, and this was further complicated by the incidence of high infant mortality that already existed. Establishing agriculture in unexploited lands required tremendous labor, and for these reasons famines and starvation existed in some settlements/outposts. Lastly the relationships between early settlers and natives varied from periods of coexistence, hostilities and war to exterminating indigenous tribes.

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