Leonard Nimoy , from my understanding of events , was the only actor offered the role of 'Spock' . Had he declined the role , Martin Landau would have been approached for playing the role .
William Hartnell was the first actor to play Dr Who in 1963.
== == Leonard Nimoy played Spock in ST-TOS.However, in the upcoming movie titled Star Trek (coming May 8th, 2009), Leonard Nimoy will only be playing the old Spock. Zachary Quinto will be playing the younger Spock.(This is due to the fact that Leonard Nimoy will be turning 78 on March 26th, 2009. Wish him a happy birthday!)
His character, Scotty, played the bagpipes at Spock's funeral near the end of the movie. But actor James Doohan mentioned in an interview that he did not actually play the instrument during the scene.
Scottish actor Brian Cox was the first actor to play Hannibal Lecter onscreen in Michael Mann's 1986 thriller "Manhunter."
Sean Connery was the first actor to play Bond in the official franchise of Bond films.
Zachary Quinto.
Jon Cryer was considered to play Chandler
Bela Lugosi in Dracula (1931) Although Max Schreck was the first actor to play Dracula in Nosferatu (1922)
William Hartnell was the first Doctor Who.
As a play the first actor to ever play Romeo was Richard Burbage around 1595. As for movies: 1908- Godfrey Tearle 1964- Leonard Whiting 1996- Leonardo DiCaprio
Lon Chaney
Actor Joel McCrea was the first one to play Doctor Kildare in the 1937 film titled Interns Can't Take Money.