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Is the gene for ankylosing spondylitis transferred from mother to son?
Ankylosing spondylitis (AS) is a complex genetic condition influenced by various genes, with the HLA-B27 gene being a significant risk factor. While genetics can play a role in the inheritance of AS, it is not strictly passed from mother to son; instead, both parents can contribute to the genetic predisposition. Environmental factors and lifestyle also influence the development of the disease, making the inheritance pattern multifactorial rather than straightforward.
Can anklosing spondylitis cause a stroke?
Ankylosing spondylitis (AS) is primarily an inflammatory arthritis that affects the spine and can lead to various complications, including cardiovascular issues. While AS itself is not a direct cause of stroke, the chronic inflammation associated with the condition can increase the risk of cardiovascular diseases, including stroke. Additionally, other factors linked to AS, such as hypertension and a sedentary lifestyle, may further elevate this risk. Regular monitoring and management of cardiovascular health are important for individuals with AS.
What is meant by little about pressure on your lungs from Ankylosing Spondylitis is the posture of your body pressing against your lungs and can it be dangerous I find myself coughing and chocking?
Ankylosing spondylitis can lead to a stooped posture, which may compress the lungs and restrict their capacity, resulting in difficulty breathing and potential coughing or choking. This compression can be dangerous as it reduces your ability to take deep breaths, increasing the risk of respiratory issues. If you're experiencing these symptoms, it's essential to consult a healthcare professional for evaluation and management. Proper posture and breathing exercises may help alleviate some of the pressure on your lungs.
Ankylosing spondylitis?
DefinitionAnkylosing spondylitis is a long-term disease that causes inflammation of the joints between the spinal bones, and the joints between the spine and pelvis. It eventually causes the affected spinal bones to join together.See also: ArthritisAlternative NamesRheumatoid spondylitis; Spondylitis; Spondylarthropathy; Seronegative bundle arthropathyCauses, incidence, and risk factorsThe cause of ankylosing spondylitis is unknown, but genes seem to play a role.The disease most often begins between ages 20 and 40, but may begin before age 10. It affects more males than females. Risk factors include:Family history of ankylosing spondylitisMale genderSymptomsThe disease starts with low back pain that comes and goes.Pain and stiffness are worse at night, in the morning, or when you are not active. It may wake you from your sleep.The pain typically gets better with activity or exercise.Back pain may begin in the sacroiliac joints (between the pelvis and the spine). Over time, it may involve all or part of the spine.You may lose motion or mobility in the lower spine. You may not be able to fully expand your chest because the joints between the ribs are involved.Fatigue is also a common symptom.Other, less common symptoms include:Eye inflammation or uveitisHeel painHip pain and stiffnessJoint pain and joint swelling in the shoulders, knees, and anklesLoss of appetiteSlight feverWeight lossSigns and testsTests may include:CBCESRHLA-B27 antigenX-rays of the spine and pelvisTreatmentYour doctor may prescribe nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce inflammation and pain.Corticosteroid therapy or medications to suppress the immune system may also be prescribed. Drugs called TNF-inhibitors (etanercept, adalimumab, infliximab), which block an inflammatory protein, have been shown to improve the symptoms of ankylosing spondylitis.Some health care professionals use drugs that block cell growth (cytotoxic drugs) in people who do not respond well to corticosteroids or who are dependent on high doses of corticosteroids.Surgery may be done if pain or joint damage is severe.Exercises can help improve posture and breathing. Lying flat on the back at night can help maintain normal posture.Expectations (prognosis)The course of the disease is unpredictable. Symptoms may come and go at any time. Most people are able to function unless the hips are severely involved.ComplicationsRarely, people may have problems with the aortic heart valve (aortic insufficiency) and heart rhythm problems.Some patients may have pulmonary fibrosis or restrictive lung disease.Calling your health care providerCall your health care provider if:You have symptoms of ankylosing spondylitisYou have ankylosing spondylitis and develop new symptoms during treatmentPreventionPrevention is unknown. Awareness of risk factors may allow early detection and treatment.ReferencesGoldman L, Ausiello DA. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007.Sidiropoulos PI, Hatemi G, Song IH, et al. Evidence-based recommendations for the management of ankylosing spondylitis: systematic literature search of the 3E Initiative in Rheumatology involving a broad panel of experts and practising rheumatologists. Rheumatology (Oxford). 2008. 47(3):355-61.Dagfinrud H, Kvien TK, Hagen KB. Physiotherapy interventions for ankylosing spondylitis. Cochrane Database, Syst Rev. 2008. (1):CD002822.
What is HLA B27?
HLA B27 is a specific protein found on the surface of cells that plays a crucial role in the immune system. It is part of the human leukocyte antigen (HLA) system, which helps the body recognize foreign substances. The presence of HLA B27 is associated with certain autoimmune conditions, particularly ankylosing spondylitis and other spondyloarthritis. Individuals with this antigen may have an increased risk of developing these disorders, although not everyone with HLA B27 will experience them.
Who is most at risk for chickenpox causing death?
The threat is greatest to newborns, who are more at risk of death from chickenpox than any other group.
What group of people are most at risk of HIV infection right now?
Sexually active people.
Because many pollutants affect development which group of people is most at risk?
children and fetuses.
What age group is affected the most by lyme disease?
people and/or animals with a risk of getting bit.
What is the formula for expected number of deaths?
The sumation (each stratum of population) of risk * population size. For example: (risk*population size of group 1) + (risk*population size of group 2) + ... + (risk*population size of group n)
What age group is the most likely to be uninsured?
Young adults age 19-29 are the most likely to be uninsured because they are most at risk for low- income households
What is the risk of developing malignant melanoma and what age group is most affected?
The risk is about 13 per 100,000 of the population. It affects all age groups but is most commonly seen in patients between 30 and 60 years of age.
