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The same 45 cal. ammo used in the 45 cal. revolver. This can get confusing, there are very different cartridges that are '.45'. In semi-automatic pistol the most common is .45 ACP.

The ACP stands for Automatic Colt Pistol, that is the company that developed the cartridge. But for revolvers, you would more commonly use the .45 LC (Long Colt) which is a longer round. Modern Derringer's are more typically a two barrel gun that shoots the revolver cartridge, at least in .45. There are many types and calibers of Derringers that have been made for a very long time. The best thing is to research the specific model of gun you have and get the manufacturers recommendations for ammunition.

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Q: What ammo do you shoot through the 45 cal derringer?
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