Fleas carried on rats.
The Great Plague of London in 1665 to 1666 is believed to have been caused by the bacterium Yersinia pestis, the same organism believed to have caused the Black Death.This, of course, was in the 17th century. I did not locate a plague in London in the 16th century.There is a link below.
The plague ceased when the great fire of London happened and finnished the epidemic in the UK by the fire killing the rats and fleas
search- What did doctors think caused the plague in 1665? this will provide you a much better, clearer answer.
The Bubonic Plague that afflicted London from 1665 was ended by the Great Fire of London in 1666.
the black death (the great plague) started in holland 1645 and then transported to London in 1665 . A bit like swine flu.
The great fire of London happened after the plague in 1666.
1665
The Great Plague, lasting from 1665 to 1666, was the last major epidemic of the bubonic plague to occur in England.
The Great Fire of London occurred Which in all probability help to wipe out the remaining infestations of the plague.
The great fire of London happened after the plague in 1666
the great fire of london
The disater in London before the great fire of london, was a out break of the plague, which is also commonly known as the black death. The plague spread through London, killing many people in the year 1665.