Get to the vet immediately!
Pregnancy.
Gallstones
HPV, Human Papilloma VirusWhat causes severe dyskaryosis
You have to take it to the vet to find out why she's sick. It might be worms which require medication.
Thalidomide.
Sometimes the stiffness is severe enough that it causes frozen shoulder.
It doesn't. Cholera kills by dehydration via the severe diarrhea it causes!
Anorexia
severe weather
Mitigation is the action that causes an occurrence to be less severe or damaging.
Gunshots, stabbing, severe lacerations, severed arteries, and broken glass just to name a few.