Interstates 70, 25, and 76, US Highways 50, 40, 24, 287, 6, and 83. .
the major highways are #29 and#133
There are many major highways in the United States. A few of the major highways are I-80, I-75, and I-70.
The major north-south highways are I-75 and I-69. The major east-west are I-94 and I-96
I-95 is one of the well known highways.
They were and still are the major transportation routes.
Highways link cities - there are no major cities in the northern part of Canada
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Maryland has a few major highways in it. Interstate 95 is one of the busiest highways in the country. It runs north and south. Also 70 and 83 run through the state.