You can't produce insulin
Glucokinase
Glucokinase Regulatory Protein is found in the nucleus which binds glucokinase to inactive it
in the cytosol
glucokinase. glucokinase has a high km(low affinity for glucose) so glucokinase only phosphorylates glucose when blood glucose is high, such as after a meal. As such, it makes sense that this would be sensor for B-cells
glucokinase
glucokinase
Hexokinase
It is not inducible by insulin
equilibriates between the nucleus and cytosol
Pancreatic Beta cells and liver hepatocytes. Read more in link.
Glucokinase is the enzyme responsible for phosphorylation of glucose in the first step of glycolysis. The glucokinase complex is modified by two different molecules: citrate and ATP. Citrate and ATP are both products of the sequence of reactions in aerobic respiration and are consequently products of glycolysis. As these two molecules' concentrations in the cell build up, they bind to the allosteric site of glucokinase and shut it down.