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Lyopobic colloid is a colloidal dispersion whereby the dispersed phase is solvent hating .i.e little interaction between the dispersed phase and the continuous phase. Lyophobic colloidal particles are not readily solvated because the continuous phase prefer to interact with one another than be involved in solvating the dispersed particles. Lyophobic colloidal dispersion does not form spontaneously when the dispersed particles and the continuous phase are brought together. The dispersed particles will tend to aggregate i.e thermodynamically favourable. However this is not pharmaceutically favourable. Dispersion method and condensation method are two methods involved in manufacturing lyophobic colloids. If the continuous phase is water, it is also called hydrophobic colloids.

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