a diverse group of congenital brain abnormalities that arise specifically from defective formation of the central nervous system .
Due to the congenital nature of neuronal migration disorders, most patients do not recover from their symptoms. The course of disease tends to be static.
The most well characterized genes include DCX on the X chromosome, responsible for double cortex syndrome, and LIS1 on chromosome 17, the first gene identified for lissencephaly.
Diagnosis is usually made by neuroimaging. CT scan or MRI of the brain will show the characteristic abnormality. MRI has better resolution and may detect polymicrogyria or small heterotopias more easily than CT.
Maybe the lineage of giant cells has to do with neuronal migration.
In lissencephaly or agyria, neuronal migration fails globally, causing the brain to appear completely smooth and have abnormal layering in the cortex.
Lissencephaly is part of a spectrum of brain malformations, which are referred to as the agyriapachygyria-band spectrum and are caused by abnormalities in neuronal migration, a critical process in brain development
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Clusters of neuronal cell bodies and dendrites in the brain are called nuclei.
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Neuronal dropout refers to the loss of neurons in the brain due to various factors such as aging, neurodegenerative diseases, or injury. This can lead to cognitive decline and impaired brain function. Strategies to promote neuroprotection and neurogenesis can help mitigate neuronal dropout.
An electroencephalograph (EEG) is a medical device used to measure and record the electrical activity of the brain. It does this by placing electrodes on the scalp, which detect electrical impulses generated by neuronal activity. EEGs are commonly used in diagnosing conditions such as epilepsy, sleep disorders, and other neurological disorders. The resulting recordings, known as electroencephalograms, provide valuable insights into brain function and health.