They include:
Biological half-life
Compounds with a half-life which is shorter than 8 hours and shorter than 2 hours are good for sustained release formulations. On the other hand, drugs with a short half life yet long duration of action are not suitable for sustained release formulations.
Absorption
The rate of release should be slower than the rate of absorption. In other words, the overall absorption rate of the drug should be consistent with the rate of release of the drug from the dosage form. Drugs which have a poor absorption are not suitable for sustained released formulations.
Metabolism
Metabolism can occur in the intestine. When compared with a bolus dose, sustained release increases the chances of the drugs being metabolised as they are released one by one.
Margin of safety and therapeutic effects
Drugs with a narrow therapeutic window are dangerous candidates as failure of choosing the correct dosage form may lead to accidental overdose.
Cost, durability, and density to name a few.
Environmental factors influence the planning and design of project planning and design in project management and planning and planning are: 1.The objective of the environmental planning. 2.The people who will use the environment itself. 3.The transportation will use in the environmental. 4.Others environmental support for the activities in the environment's.
There are many factors that influence the crystallization process. Some factors are impurity level, mixing regime, vessel design, and cooling profile.
design influence income
Patterns in the organization of purchasing, identi- fied contextual factors that influence its design or analyzed the contribution of the PO to purchasing.
Designs need to satisfy the following in varying degrees: User needs and desires; Manufacture; Business; Environment and Social concerns; Designers own beliefs, values and need for expression.
aspect influence the design
factors of operating system design
Environmental issues (e.g. creation of waste products) Design and layout of factory, equipment, offices
Good furniture design is a combination of form and function. The piece must be useful for its intended purpose. It must also be pleasing aesthetically.
sample design
There are many kitchen design types available in the market. Some of them are mentioned below: 1. A quiet space kitchen. 2. An open space kitchen. 3. Functional cooking space.