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As the carbon chain of the drugs get longer, the drugs become more lipophilic. The more lipophilic the drugs are, the more easily they can penetrate biological barriers or cell membranes. However, drugs that are too lipophilic may be precipitated out due to their lower solubility in water and this prevents them from entering cells.

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6y ago
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6mo ago

Some trends for drugs in a homologous series include increasing molecular weight and size with an increase in the number of carbon atoms in the chain. This can affect the drug's potency, pharmacokinetics, and metabolic stability. Additionally, there may be trends in solubility, lipophilicity, and protein binding affinity as the alkyl chain length varies.

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Q: What are some trends for drugs in a homologous series?
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