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Congenital erythropoietic porphyria (step 4); porphyria cutanea tarda (step 5); hepatoerythopoietic porphyria (step 5); erythropoietic protoporphyria (step 8).

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Q: What are the 4 different steps at which heme biosynthesis defects occur with non-acute porphyrias?
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What are the 4 different steps at which heme biosynthesis defects occur with acute porphyrias?

ALA dehydratase deficiency porphyria (step 2); acute intermittent porphyria (step 3); hereditary coproporphyria (step 6); variegate porphyria (step 7).


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Heme biosynthesis is significant because heme is a crucial molecule involved in many important biological processes, such as oxygen transport, energy production, and drug metabolism. Defects in heme biosynthesis can lead to various disorders, including porphyrias, which are characterized by abnormal heme production and can result in symptoms such as skin sensitivity to sunlight, abdominal pain, and neurological symptoms. Understanding heme biosynthesis can help in the diagnosis and treatment of these disorders.


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How do you spell defects?

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