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What are the Five major types of alkylating agents?

Updated: 8/18/2019
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žNitrogen mustards: such as mechlorethamine (nitrogen mustard), chlorambucil, Cyclophosphamide (Cytoxan), ifosfamide, and melphalan

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žNitrosoureas:streptozocin, carmustine (BCNU), and lomustine

žAlkyl sulfonates: busulfan

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žTriazines: dacarbazine (DTIC) and temozolomide (Temodar)

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žEthylenimines: thiotepa and altretamine (hexamethylmelamine)

žThe platinum drugs (cisplatin, carboplatin, and oxalaplatin) are sometimes grouped with alkylating agents because they kill cells in a similar way.

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