A major problem encountered in the transdennal delivery of drugs is the effectiveness of the barrier system imposedby the stratum corneum.To overcome tbe resistance of the skin to the ingress of exogenous chemicals, numerous innovative techniques requiring complex delivery systems have been studied. Many of these systems attempt to alter the barrier potential by the use of enhancer technology. Supersaturation, on the other hand, is a simple and economical technique which is not intended to modify the physical structure or the chemical compositionof the stratum corneum, yet may effectively deliver a markedly greater mass of drug to the skin than that achieved by the use of conventional, saturated solutions. Supersaturated systemsmake use of the elevated thermodynamic activity of the permeant in the deliveryvehicle, which results in higher flux rates across the contacting membrane by increasing the concentration gradient
Supersaturated.
A supersaturated solution is obtained.
Supersaturated.
Supersaturated
This is a saturated solution.
Supersaturated.
The solute will eventually fall out of a supersaturated solution
The solute will eventually fall out of a supersaturated solution
A supersaturated solution has two phases: liquid and solid.
Adding more solute the solution become supersaturated.
A solution become supersaturated when the limitt of solute solubility at a given temperature is exceeded.
How a saturated solution can become supersaturated?
A supersaturated solution has a concentration of solute greater than the solubility at a specific temperature.
A supersaturated solution is obtained.
Supersaturated.
Supersaturated
A supersaturated solution contain an amount of solute higher than the limit of solubility at a given temperature and pressure.