What are the examples of pharmaceutical suspension?

Answer 1

Pharmaceuticl suspensions are solid dipersion of insoluble or sparingly-soluble drugs, in aqueous or oily vehicles. They are intended for oral administration, topical application or parenteral administration of drugs.

Aerosol suspension of finely divided, or micronized drugs, is also another class of pharmaceutical preparations intended for inhalation.

Suspension of drugs for oral administration is an easy way to administer insoluble, or sparingly soluble, drugs to infants and eldery who have difficulty in administering drugs in tablet or capsule forms. Also for rapid absorption of some insoluble drugs, which are slowly absorbed from tablet dosage form, such as griseofulvin, prepared in suspensions form of the micronized drug.

The insoluble basic drug, or the insoluble salt or compound of a drug, is frequently used rather than using the soluble salt, to retard absorption of the drug. This is used for the preparation of prolonged released dosage forms to avoid frequent administration of the drug.

Sometimes insoluble salts or compounds of the dugs are used to avoid the bitter taste of the soluble form; for example the use of chloramphenicol palmitate in suspension, instead of using the very bitter soluble chloramphenicol.

Some eye drops or ear drops are also prepared in suspension form for drugs which are sparingly soluble, or intenetially using the insoluble form to prolong the time of action of the drug, such as corticosteroid preparations. Samir M. Bayoumi

Prof. of Pharmaceutics

samir.bayoumi@mcphs.edu

Answer 2

The effects depend on the pharmaceutical drug.

Ideally, you would want a suspension that doesn't have any effects on its own.

Maybe you mean what are the implications of delivering drugs as a suspension instead of other methods?

A suspension is when you have a solid drug in a liquid delivery, but the solid is not dissolved. Instead, it is floating suspended in the liquid.

The advantage to this is that you are essentially administering a ground up tablet in a convenient liquid oral delivery.

One disadvantage is that the solid that is suspended can settle to the bottom, so it is important to always shake a pharmaceutical suspension before taking it.

Answer 3

• · Suspension is usually applicable for drug which is insoluble or poorly soluble. E.g.

Prednisolone suspension

• · To prevent degradation of drug or to improve stability of drug.

E.g. Oxytetracycline suspension

• · To mask the taste of bitter of unpleasant drug.

E.g. Chloramphenicol palmitate suspension

• · Suspension of drug can be formulated for topical application e.g. Calamine lotion

• · Suspension can be formulated for parentral application in order to control rate of drug

absorption.

• · Vaccines as a immunizing agent are often formulated as suspension.

E.g. Cholera vaccine

• · X-ray contrast agent are also formulated as suspension.

E.g. Barium sulphate for examination of alimentary tract