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What are the causes of sickle-cell disease?

Updated: 8/18/2019
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11y ago

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Sickle-cell Disease (SCD) is more common in those of African and Mediterranean decent; these people carry the sickle-cell trait; but not all who carry this gene develop the disease. This disease is caused by a genetic defect in an amino acid which shows in those who inherited this blood disease; SCD causes abnormal hemoglobin. This disease causes anemia which is caused by this mutation in the body's hemoglobin, B-globin chain. The abnormal gene causes irregular compounds in the red blood; hence the name Sickle-cell disease. The altered shape (crescent moon form) of the proteins inside of red blood cells causes them to clump and stick together leading to health issues.

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Q: What are the causes of sickle-cell disease?
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