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The main differences include:

# Archaea have cell membranes composed of glycerol-ether lipids, while bacteria have glycerol-ester lipids. # Archaeal membrane lipids are also unique because the stereochemistry of the glycerol group is the reverse of that found in other organisms. # Archaea use methionine to start protein synthesis, bacteria use formylmethionine. # Archaea don't utilize chlorophyllfor photosynthesis and do not generate oxygen as byproduct of it. # Archaea are methanogenic. # As a general rule, Achaea can withstand more severe conditions than most bacteria. (ie. are extremophiles).

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