in 1534, Holy Roman Emperor Charles V ordered the fist survey of a proposed canal route across the Isthumus of the Panama. The survey came back "impossible."
Panama City, Panama or Panama City, Florida? I just came across this question and am not entirely sure, but assuming you mean Panama City, Panama, then come on down. It's perfectly safe for tourism.
Panama. It moves ships across Panama.
diseases
The Panama Canal
The Panama Canal workers suffered from deadly endemic diseases. These were known as yellow fever and malaria. These diseases practically disabled many and killed at least 20k workers in the 1880's.
He brought across foreign diseases which killed off the native Americans. These diseases spread across the country via the natives, quicker than Columbus and his men were travelling. Therefore they even came across settlements where all the natives were already dead.
tropical diseases
Across the Isthmus of Panama in 1912 - 1912 was released on: USA: 15 March 1912
Panda!
the canal
Your answer is the Panama Canal, in of course, Panama.