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I'm not 100% sure what you mean, but I'll answer how I took the question...

If you take vicodin on an empty stomach, it'll hit you harder and faster than if you took it on a fuller stomach or while eating. But, if you take it on an empty stomach the chance of it making you nauseous are much higher. Hope this helps :)

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Q: What are the effects of food on Vicodin?
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